Archive for December, 2009

Cryopyrin Associated Periodic Syndromes (CAPS)

Monday, December 21st, 2009

CAPS (cryopyrin-associated periodic syndrome) is a group of rare genetic diseases that can cause rashes, fevers, joint pain, and other inflammatory symptoms. These symptoms often occur after exposure to cold or damp air or a drop in temperature, but symptoms may also show up for no clear reason. Cryopyrin is a protein responsible for triggering the inflammation and painful symptoms of CAPS. A malfunction in this protein is what these diseases have in common. Three syndromes comprise CAPS: Familial Cold Auto-inflammatory Syndrome (FCAS), (previously termed Familial Cold Urticaria), Muckle-Wells Syndrome (MWS) and Neonatal-Onset Multisystem Inflammatory Disease (NOMID), which also is referred to as Chronic Infantile Neurologic Cutaneous Articular Syndrome (CINCA).

Familial Cold Autoinflammatory Syndrome is the most common and least severe type.
* Symptoms: Rash, headache, fever, feeling tired, sore or red eyes, and muscle or joint pain
* Onset of symptoms: At birth or, rarely, later in childhood
* Trigger of symptoms: Exposure to cold temperature
* Duration of symptoms: Typically last no more than 24 hours

Muckle-Wells Syndrome is more severe than FCAS.
* Symptoms: Those symptoms listed above, as well as loss of hearing. High protein levels are detected during screening and are a sign of the disease
* Onset of symptoms: At birth or, rarely, later in childhood
* Trigger of symptoms: Exposure to cold temperature, weakness of the body, or other reasons that are not yet known
* Duration of symptoms: Usually last between 1 and 3 days

Neonatal-Onset Multisystem Inflammatory Disease is the most severe type.
* Symptoms: All of the above mentioned symptoms, as well as loss of eyesight, swelling of the knees, and mental disability
* Onset of symptoms: Almost always at birth
* Trigger of symptoms: Reasons that are not yet known
* Duration of symptoms: Continuous with symptoms worsening from time to time

Diagnosis of CAPS is often missed due to the rarity of these conditions (low index of suspicion). Furthermore, some symptoms of CAPS may be similar to findings of more common diseases such as systemic JIA and systemic lupus erythematosus. Some features of FCAS may be mistaken for Acquired Cold Urticaria (ACU), a more prevalent condition. Both demonstrate cold-induced rash; however, in ACU, the rash is usually localized to sites of direct cold exposure, whereas in FCAS, the inflammation is more generalized, being systemic in nature.

Cryopyrin-Associated Periodic Syndromes are a rare and newly discovered group of autosomal-dominant disorders that can best be diagnosed through analysis of family history, compilation of clinical history, including age of primary presentation and frequency/duration of episodes, physical examination, laboratory and histological testing, and genetic analysis. Not all CAPS patients have detectable genetic mutations.

Are you or other family members troubled by recurring rashes, fevers, aching joints, and other symptoms? It’s time to take action. Learn about CAPS – Cryopyrin-Associated Periodic Syndromes, a group of rare genetic diseases that runs in families and can be passed down through generations at Take a few minutes to complete the screener. Your answers can help you take a more active role in your medical care, and that of others.

Purchase Medical Supplies Online

Monday, December 21st, 2009

Medical supplies have made their way into the online shopping lists of many people. A good online medical store can make your purchase very convenient. Here are the reasons that made online shops selling medical items so much successful:

Secure Payment Methods: If you are buying a product on the Internet, you will probably never want that someone hacks into the wire and steals your credit card information. In order to prevent any such risk to their customers, online stores offer you very secure payment gateways. The whole information you enter on your computer is first encrypted. This encrypted information is then sent via the wire to the server where it is decrypted and your login is authenticated. A trespasser trying to steal it on the way won’t be able to use the encrypted form. Professionals and companies that buy Medical supplies often have huge credit limits on their credit cards. Secure transactions are therefore very important for them.

Quality Assurance: Common buyers are tempted to doubt on the credibility of the products and services sold online. However, with experience they learn that online stores supply very good quality, most of the times even better than your local stores. There is a tough and constant competition between the online stores, and to get successful they must give consistently good quality to their customers. The only way they can inspire customer goodwill and get bigger orders is by delivering high-grade products. This is the reason the medical supplies available online are very reliable.

Discounted Rates: On the Internet, the customer is free to browse through the different websites and compare the prices of the product he wants to buy. Online stores keep their prices reasonable so that the customer finds buying from them the best deal available. In order to attract large orders, online stores also offer substantial discounts on bulk purchases of medical supplies or other items.

If you need good quality medical supplies for your office or healthcare center, browse . This is an online store offering the most popular medical equipment & medical supply products, such as portable oxygen concentrators, wound care dressings, CPAP supplies and much more at very competitive pricing.

Ability Medical Supply is committed to providing for all your home medical equipment and supply needs and stand by their promise with guaranteed service. They do this by consistently offering quality brand name products, competitive pricing and exceptional customer service. Should you require an item not listed, or if your needs are specialized, please contact them. Their experts are here to help you. Shop the Ability Medical Supply and Save!